Enzyme as a thermal resonance pump

We found latent periodicity of 150 protein families now. We suppose that latent periodicity can determine a spectrum of resonance oscillations in proteins. Method of Information Decomposition (ID) of symbolical sequences permitted to reveal the latent periodicity of amino acid sequences (AAS). Latent periodicity (LP) found by the ID method was used as the primary profile for search of the LP in protein families with the possibility of deletions and insertions of the symbols in AAS. Swiss-Prot data bank was scanned by the primary profile with using of the modified profile analysis for search of AAS that have a statistical important level (score>6.0) of cyclic alignment against the primary profile. After this scanning the profile was recalculated with using of found cyclic alignments that belong to the protein family where the primary profile was detected. At the same time cyclic alignments belong to other protein families were considered as a noise. The recalculated profile was used for the new scanning of Swiss-Prot data bank. New statistical important AAS with cyclic alignment against the recalculated profile were not revealed after 5-7 iterations. And as result the LP was revealed for more than 80% of proteins from the protein family where the primary profile was detected firstly. At the present time different types of the LP were found in the 150 protein families, such as protein kinases, cytochromes, NAD+ binding sites. These protein families contain more than 6 thousands of proteins from Swiss-Prot data bank. Full list of the proteins families can be received from web sites http://bioinf.narod.ru/periodicity100 and http://bioinf.narod.ru/periodicity/new. Fig shows the example of the LP for NAD+ binding site. Received results show that LP is common property for many protein families having different biological functions. Different protein families have different types of the LP.